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Targeting glutamate signalling in depression: progress and prospects | Nature Reviews Drug Discovery
This SF-induced activation of the so-called “stress proteome” may involve at least two widely studied and interrelated cellular signaling pathways: the regulation of the Keap1/Nrf2/ARE cytoprotective genes, and the HSP/proteasomal pathway, both of which play a role in protecting against a wide variety of disturbances of cellular function [21]
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In der am meisten bevorzugten Ausführungsform werden die Inhibitoren eingesetzt in einer Konzentration von 3,5 bis 5,5 Gew.-% für den kompetitiven und 0,75 bis 1,25 Gew.-% für den nichtkompetititven Inhibitor, jeweils bezogen auf das Gesamtgewicht der Zusammensetzung