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The role of IGF-II should be viewed in the light of Efstradiadis series of knock-out experiments in mice (21) where the Igf2 ko mice had the same degree of fetal growth retardation as the igf1 ko which demonstrates that IGF-II is a paracrine/autocrine and not an endocrine hormone

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1 Introduction Neurodegenerative disorder constitutes a substantial and growing global healthcare challenge, which entails the deterioration of neurons in a stepwise manner, resulting in dementia, motor, and other functional impairments (Pasko et al., 2022)

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