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Others try taking a histamine-degrading enzyme, diamine oxidase (DAO) , hoping it will allow them to enjoy coffee without symptoms
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Other studies have found that the MAPK pathway (which has a critical role in regulating cisplatin-induced apoptosis) cannot be activated in cisplatin-tolerant cells, and, as a result, the FAS/FASL system (an inducer of extrinsic apoptosis) cannot be activated to enable cell survival (Spierings et al., 2003)
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