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Consistent with this, the observation of reduced viability of H9c2 cardiomyoblasts and HUVEC endothelial cells to values below 80% when incubated with GSNO concentrations above 75 μm and 156 μm, respectively, indicates that the cytotoxic effect of high GSNO concentrations, such as 500 μm, may prevail over the beneficial effect of cardioprotection in I/R
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