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doi: 10.3389/fcell.2025.1660433 Received 06 July 2025 Revised 08 December 2025 Accepted 23 December 2025 Published 12 January 2026 Volume 13 - 2025 Edited by Yan Chun Li, The University of Chicago, United States Reviewed by Sergey Yaklichkin, Memorial Sloan Kettering Cancer Center, United States Jingchao Wang, Harvard Medical School, United States Updates Copyright © 2026 Kang and Cheng