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Growth of the Cgatg1 Δ strain was suppressed during the 96-h co-incubation, whereas growth of the wild-type strain and the CgATG1 -reconstituted strain was increased despite phagocytosis by macrophages (Figure 5A)

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On the other hand, CTB’s strong binding affinity for the ganglioside GM1, which is ubiquitously expressed on most mammalian cell types, improves uptake by immune modulatory cells such as macrophages, DC, T, B, or mast cells [132, 134, 135]