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Trimethylglycine (TMG) supports methylation, liver health, and homocysteine metabolism while acting as a cellular osmolyte for stress resilience.* TMG assists homocysteine to be metabolized into methionine, resulting in the production of DMG (dimethylglycine).* The two major functions of TMG in humans are as an osmolyte to protect cells under stress and as a methyl-group donor.*
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Interestingly, HA in PCOS is an independent risk factor for NAFLD, as demonstrated in a recent systematic review and meta-analysis (101, 106)