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Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin

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On the basis of these findings, noting that combination CFTR modulator therapy is currently approved for treatment of patients with F508del-CFTR and has been shown to improve MCT in F508del-homozygous primary HBE cells in correspondence to clinical benefit (32, 36), we assessed the impact of ARINA-1 in combination with the corrector lumacaftor and potentiator ivacaftor, applied basolaterally 18 hours before ARINA-1 addition to simulate chronic exposure (32)