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Excess Iron Deposition and Toxicity in Non-Transfusional Iron Loading Conditions There are many non-transfusion-dependent iron overloading conditions affecting millions of patients worldwide, including idiopathic hemochromatosis, thalassemia intermedia, and transfusion-independent post-allogeneic HCT patients, which was introduced in previous sections (Table 1) [10,42,43,47,116,117,118,119,120,121,122]