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In hepatocytes, ATP7B plays a crucial role in facilitating the p62-mediated release of copper from intracellular stores into the cytoplasm, thereby enabling the excretion of surplus copper through its incorporation into bile (33)

Laboratory Research

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In another study, apatinib also improved the levels of T helper 1 (Th1) and T helper 2 (Th2)-like cytokines (107)