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doi: 10.1021/ja076118y

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Preclinical studies have demonstrated apoptosis induction 35-37 and multiple other mechanisms for ALA’s antineoplastic properties, including regulating mitochondria respiration, 35,38 inducing endoplasmic reticulum (ER) stress, 39 inhibiting nuclear factor-kappa B (NF-kB), 40 inhibiting transforming growth factor beta (TGF-β) signaling and epithelial to mesenchymal transition, 35 and epigenetic modification