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Improvement was noted at each of four evaluations, and lasting improvement was attributed to the biofeedback portion of treatment program

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Post-transcriptional IL-1β exists solely in the inactive Pro-IL-1β form, which has to be cleaved by the NLRP3 inflammasome-activated effector protein caspase-1 for activation, and this activated form then exerts the proinflammatory effects (40)