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Thyroid antibodies (anti-TPO and anti-thyroglobulin) are added when Hashimoto's is suspected — they can be elevated years before TSH becomes abnormal and confirm autoimmune thyroid disease as the underlying driver of symptoms

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Observational studies A large number of cross-sectional and prospective cohort studies have associated elevated blood homocysteine concentrations with measures of poor cognitive scores and increased risk of dementia, including Alzheimer's disease (reviewed in 67, 69)