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It acts as a signaling molecule that: Activates tissue repair pathways Stimulates collagen and glycosaminoglycan synthesis Promotes angiogenesis Modulates inflammation via NF-κB suppression When endogenous levels fall, regenerative capacity falls in tandem
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With heterochronic sham parabiosis, hypertrophy in old mice was not reduced, implying the presence of a circulating factor that regulated cardiac size
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