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however, an obvious delay in the assembly of other TJ proteins including occludin and claudins into the TJ is observed, indicating that the ZO proteins have an important role in the regulation of TJ assembly.38 REGULATION OF THE TJ PROTEINS The roles of cytokines in intestinal TJ regulation under pathophysiological conditions have been well investigated

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Accordingly, adjuvant vitamin B12 has been shown to increase methylation of key genes in inflammatory disorders, resulting in their downregulation