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Although some cases may be regarded as anecdotal, in our view there are at least three convincing ones: one with nalidixic acid (Alessio & Morselli, 1972), one with ciprofloxacin (Sansone et al , 2010), and one with ofloxacin (Carmoi et al , 2009)

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The calculation can also be done using minerals that are not affected by the chemical treatment regime, such as chloride or silica