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Activation of the HGF/c-Met system has been shown to possess neuroprotective/neurorestorative activity related to amyotrophic lateral sclerosis (Kadoyama et al., 2007), Parkinson’s disease (Koike et al., 2006

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Notably, in an isoproterenol (ISO)-induced ischemia/reperfusion (I/R) injury model, GA not only decreased the activity of cardiac biomarkers (CK-MB, CPK, and LDH) but also increased the activity of lysosomal enzymes such as β-glucuronidase and cathepsin D (Shackebaei et al., 2022), and in ISO induced MI in rats, GA also reduced serum cardiac troponin T (cTnT) level and the intensity of LDH-1 and LDH-2 isoenzyme bands (Priscilla and Prince, 2009)