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Ward et al., 2019), including muscular pain, nocturnal muscle cramping, weakness, rare rhabdomyolysis, and amyotrophic lateral sclerosis (ALS)-like muscle wasting conditions ( Previous studies about SAMS focused on skeletal muscle, and the majority of mechanisms were centered on mitochondrial dysfunction, oxidative stress, immune-mediated necrotizing myopathy, and inhibition of isoprenylation of small G-proteins, owing to impaired mevalonate metabolism upon skeletal muscle damage (Thompson et al., 2016
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