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CD40 genetic variants affect susceptibility to lupus in conjunction with EBV.[ref] A 2025 study showed that EBV-infected B cells can activate helper T cells, which starts a cascade of events leading to the systemic autoimmune response.[ref] Related article: Lupus: Genetics, Root Causes, and Possible Solutions Multiple Sclerosis: Multiple sclerosis (MS) involves inflammation and demyelination of neurons in the brain and spinal cord