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As a result the barrier function is severely compromised due to osmotic imbalance of enteric epithelial cells leading to increased permeability and invasion by luminal aggressive and noxious factors including bile acids, pancreatic secretions, hydrolytic/proteolytic enzymes and gram negative bacteria
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It was found that epimedium glycosides markedly ameliorated apparent symptoms, increased organ indices of the uterus, spleen and thymus and ameliorated pathological changes in the ovaries in model rats
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