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Acid-sensitive linkers use a lower pH in the endosomal (pH = 5-6) and lysosomal (pH = 4.8) compartments, in contrast to cytosol (pH = 7.4) to trigger hydrolysis of acid labile groups within a linker such as hydrazone

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The researchers found that adding just a microscopic amount of Vitamin B12 to the blood cultures of these patients successfully normalized the mRNA levels of CCL11