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NOS activity produces NO gas that reacts non-enzymatically with cysteine residues in glutathione, major non-protein thiol and protein-thiols to form S-nitrosoglutathione (GSNO) and S-nitrosothiols in a process known as S-nitrosation

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In the short-term, however, the paper emphasizes the importance of nailing down just how metabolites within different compartments operate within our cells