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GS-TNB is further reduced to GSH and TNB by glutathione reductase and NADPH is oxidized in the process

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SFN promotes the phosphorylative degradation of β-catenin while concurrently suppressing downstream targets including c-Myc and cyclin D1, effectively dismantling the transcriptional program that drives CSC self-renewal ( Complementing this mechanism, SFN demonstrates sophisticated regulation of the Notch pathway through a cascade of molecular events