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Where a laboratory requires a documented stability profile for its own quality system, the practical approach is to hold retained aliquots under the intended storage conditions and re-inject them by HPLC at defined intervals, comparing the main-peak area against the release chromatogram supplied on the certificate

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The free iron and lipid peroxides released from dying cells further recruit more macrophages and promote their M1 polarization, forming a vicious “inflammation-ferroptosis” cycle that accelerates plaque necrotic core expansion and instability