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Other anti–TGF-β candidates in the scleroderma clinical trial pipeline include MK-2 225, a ligand trap for TGF-β1 and TGB-β3 (NCT04948554) and RO7303509, a TGF-β3–specific immunoglobulin G1 antibody (NCT05462522)

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Weight loss itself affects hormone levels, sex hormone binding globulin, and the distribution of steroid hormones between free and bound fractions