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Considering that 2-ODDs are present in prokaryotes that lack ascorbate, the enzymes may vary in likelihood of uncoupled reaction cycles occurring as well as ability to use a thiol reductant [137]

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Interestingly, we found that in both in vitro and in vivo studies 7KCh exerts a prominent dose-dependent chemoattractive effect on retinal microglia, an effect that was specific to 7KCh and absent for non-oxidized cholesterol of a similar concentration range