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Liver-nervous system axis: pathways, dysregulation, and translational perspectives | Journal of Neuroinflammation | Springer Nature Link

In addition to its essential role in maintaining homeostasis through the regulation of inflammatory and immune responses, HO-1 is also closely associated with genetic polymorphisms that influence physiological equilibrium (9, 43)

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While historically listed with an "unknown status," recent data releases in late 2025 and early 2026 have clarified the safety profile that helped justify the Category 1 reclassification.​ Study Design: A randomized, placebo-controlled, double-blind Phase 1 pilot study