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The priming phase is initiated when DAMPs or PAMPs engage receptors such as toll-like receptors (TLRs) or cytokine receptors, triggering the NF-κB pathway to increase mRNA levels of NLRP3, pro-IL-1β, and pro-IL-18 (Zahid et al., 2019)

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A study indicates grape seed extract (GSE) helped improve fatty liver and lowered 46% of liver enzyme (ALT) levels more effectively than vitamin C in patients with liver fat buildup