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A recent study showed that artemisinin inhibits PDXK, and a downstream effect is decreased GABA.[ref] Leukemia caution: Talk with your doctor if you have leukemia (AML) before supplementing with vitamin B6, since it may help accelerate the disease.[ref] Safety and side effects of supplemental vitamin B6: Neuropathy at high doses: In addition to the cautions above about excess pyridoxine inhibiting PDXK, leading to a decrease in active P5P, which causes peripheral neuropathy , there are other side effects from excess vitamin B6
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