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Importantly, each different member of these subfamilies, depending on its fatty acid and amine moieties, can modulate the activity of one or more different receptors that in a few cases, have been suggested to be also targeted by AEA or 2-AG (Table 14), although often at concentrations higher than those required to activate CB 1 R and CB 2 R (Di Marzo, 2018

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Methotrexate decreases PP2A methylation and increases tau phosphorylation in neuron