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In general, there is the cytoprotection concept: the described effects of the stable gastric pentadecapeptide BPC 157 (that has been found to be safe in ulcerative colitis trials, phase II, without a lethal dose (LD1) in the toxicology studies) were ascribed to its particular cytoprotective capabilities and pleiotropic background as an acting cytoprotective peptide that protects cells and may cure muscle disturbances in particular [11,12,13,14,24,25]
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Advances in the technology of cell culture, including biologically informed selection of defined growth factors and new plating methods, have facilitated the development of new patient-derived models 5,18,19,20,21,22,23,24,25
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