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The terms “cationic lipid” and “amino lipid” are used interchangeably herein to include those lipids and salts thereof having one, two, three, or more fatty acid or fatty alkyl chains and a pH-titratable amino head group (e.g., an alkylamino or dialkylamino head group)

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• Adding glucuronic acid (pKa 3—3.5 alters the charge on the metabolite relative to parent drug, • Adding glucuronid acid increases the polarity, thus influencing membrane transport, tissue distribution