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RNAseq of PDX samples Total RNA was extracted from breast tumour xenografts samples by using miRNeasy Mini kit (#217004, Qiagen) according to the manufacturer’s procedure, treated by RNase-Free DNase (#79254, Qiagen), quantified and quality-controlled using a 2100 Bioanalyzer (Agilent)

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Correlations between static and dynamic parameters of glutathione synthesis were determined with the use of the Spearman’s rank correlation coefficient