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The rationale for combining both peptides in research protocols is based on their complementary molecular mechanisms: TB-500 acts on the actin cytoskeleton and cell migration, while BPC-157 modulates angiogenesis through the NO/VEGF pathway

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CBF reductions Individuals and animals with AD exhibit reductions in CBF and impaired cerebrovascular reactivity, particularly in the hippocampus, thalamus, frontal, and occipital cortices, as assessed by arterial spin labeling magnetic resonance imaging [157, 177, 178]