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The two compounds engage GH biology from opposite directions: AOD-9604 is downstream of GH release — a fragment that retains specific GH biological activity (lipolysis) without engaging GH receptors Tesamorelin is upstream of GH release — a GHRH analog that prompts the pituitary to release endogenous GH Origin Comparison This is a fundamental distinction

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10.1155/2018/7219732 [DOI] [PMC free article] [PubMed] [Google Scholar] Bertocchi I., Eltokhi A., Rozov A., Chi V., Jensen V., Bus T., et al