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Introduction Immunotherapy in a neoadjuvant setting is a promising approach to complement definitive surgery in head and neck cancer ( Oral squamous cell carcinoma (OSCC), the most common type of head and neck cancer, is typically treated with surgical resection followed by irradiation or chemotherapy if indicated ( We performed an open-label, single-agent pilot study to evaluate neoadjuvant topical imiquimod’s antitumor activity and safety in patients with early-stage OSCC
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