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In brain tissue, misfolded proteins such as amyloid-beta and tau can sequester copper ions, creating local copper deficiency while simultaneously generating reactive oxygen species through aberrant metal-protein interactions

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Similarly, L-S,R-buthionine sulfoximine treatment of MDA-MB231 human breast carcinoma cells enhanced 2-deoxy-D-glucose–induced cytotoxicity (Andringa et al., 2006)

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