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Clinical outcome data directly linking MIPD-guided aminoglycoside dosing to reduced ototoxicity rates remain lacking and represent an important evidence gap ( Physiologically based pharmacokinetic (PBPK) modeling offers a complementary approach by integrating developmental physiology, including age-dependent changes in body composition, renal maturation, and drug distribution, with drug-specific physicochemical parameters to predict drug disposition across pediatric age groups ( Extended-interval dosing Extended-interval (once-daily) dosing is widely adopted and preferred in many pediatric settings

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demonstrated that SFN treatment diminished prostate cancer stemness traits, including the enhanced activity of aldehyde dehydrogenase 1 (ALDH1), enrichment of CD49f + fraction, and sphere forming efficiency