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In man, UA is the final product of purine catabolism ( DUAL ROLES OF URIC ACID IN AODS Contrary to the traditional understanding as a metabolically inert and waste compound without any physiological significance, UA is a natural antioxidant contributing to approximately 60% of the free radical scavenging activity in human blood ( Uric acid is a selective antioxidant ( Figure 3 ) that removes superoxide by preventing the degradation of superoxide dismutase and subsequently inhibits its reaction with NO to form peroxynitrite ( + -induced depolarization amplifies neuroprotection provided by UA through a mechanism involving Ca 2 elevation and extracellular signal-regulated kinases½ (ERK 1/2 ) activation ( Figure 3 )
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[DOI] [PubMed] [Google Scholar] 51.Agarwal A., Saleh R.A., Bedaiwy M.A
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