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In contrast, exposure above a certain threshold (≥ 4 mg/L) disrupts microbial balance, reduces the abundance of beneficial taxa, promotes enrichment of potentially pathogenic bacteria, and suppresses the expression of genes involved in metabolism and detoxification, ultimately leading to intestinal barrier impairment and inflammatory responses [10]

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Knockdown of ARNTL2 significantly decreases the expression levels of Nrf2, SLC7A11, and CDGSH iron-sulfur domain protein 1 of lung adenocarcinoma cells, and increases the sensitivity to ferroptosis