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An oncolytic adenovirus (ADV) DNX-2401, in combination with pembrolizumab (anti-PD-1 antibody), delivered intratumorally and showed an increased OS of 52.7 % in one year with mOS of 12.5 months in a multicentric phase I/II clinical trial on GBM patients [53]
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Evidence indicates that the levels of these compounds in the leaves are generally low and unlikely to cause significant harm
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